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Cardinals vs 49ers

Cardinals vs 49ers: NFL 2021 live stream free online

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Cardinals vs 49ers: NFL 2021 live stream free online. Get ready for an NFC West battle as the Arizona Cardinals and the San Francisco 49ers will face off at 4:25 p.m. ET on Sunday at State Farm Stadium. Arizona is 4-0 overall and 1-0 at home, while San Francisco is 2-2 overall and 2-0 on the road. The Cardinals easily handled the Los Angeles Rams last Sunday, 37-20. San Francisco lost to the Seahawks, 28-21.

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Cardinals vs 49ers
Date: Sunday, October 10, 2021, Time: 4:25 p.m. ET
Location: State Farm Stadium, Glendale

San Francisco, which is in its fifth season under coach Mike Shanahan, is coming off a 28-21 loss to the Seahawks, the team’s first NFC opponent this season. The 49ers trailed by as many as 14 points in the third quarter and were unable to make a comeback, as they could not build on a late touchdown score in the final two minutes.

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Cardinals vs 49ers xKey Matchup: The Arizona offensive line will get a test against the 49ers’ pass rush. Defensive linemen Nick Bosa (four sacks) and Dee Ford (three) have been a problem for opposing teams all season. Arizona’s line has held up remarkably well considering injuries to multiple starters. The Cardinals could get a boost if RT Kelvin Beachum (ribs) is able to return.

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The Cardinals are first in the league in points and total yards per game. QB Kyler Murray has thrown 9 touchdown passes and rushed for 3 more, and is third in the NFL in passing yards through four weeks. Arizona has allowed the ninth-fewest points in the league as opponents have only scored 30 second-half points against them.

Cardinals vs 49ers key injuries


CB Byron Murphy (ribs) out

CB Marco Wilson (ribs) is questionable

RB Chase Edmonds (shoulder) is questionable

RT Kelvin Beachum (ribs) is questionable

TE Maxx Williams (shoulder) is questionable


QB Jimmy Garoppolo (calf) out

TE George Kittle (calf) doubtful

CB K’Waun Williams (calf) out

DT Javon Kinlaw (knee) is questionable


  • The 49ers have committed the eighth-most turnovers in the league (6), and are up against the third-ranked team in terms of turnovers forced, the Cardinals (9).
  • Arizona allows a score on 61.5% of its opponents’ red-zone trips (16th in the league), while San Francisco’s offensive red-zone percentage is 100.0% (first).
  • The 49ers convert 37.5% of their third-down plays (21st in the league). The Cardinals’ defense gives up third-down conversions at a 32.6% clip (sixth).
  • San Francisco’s running game ranks 12th in the NFL (114.5 yards per game). Arizona gives up 135.8 rushing yards per game (26th).

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One week after throwing for a season-high 398 yards, 49ers QB Colin Kaepernick regressed in Week 10. A player who continues to struggle with his accuracy on deeper routes, it was the Cardinals’ No. 1-ranked defense that benefited from Kaepernick’s inefficiency downfield.

Cardinals vs 49ers Picks

The Cardinals are at home and are favorites (and undefeated) for a good reason. With Jimmy G now out, Trey Lance will get his chance to start in his first NFL game and could have a tough day against the Cardinal’s defense. Arizona should take care of business and remain undefeated this season as they appear to be one of the best teams in the NFL.

One of the reasons San Francisco has struggled is because they don’t force turnovers. In four games, they have just one takeaway, an interception in week one. Since then, nothing. They are tied with the Jaguars for the fewest takeaways in the NFL.

Outside of one snap in Week 3, Lance has spent all of his time at QB with the 49ers. So the rookie has been able to fully concentrate on his responsibilities under center. And while his action has been limited in the NFL, good things have happened when he’s been on the field.

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